Leukotrienes stimulate insulin release from the rat pancreas.
نویسندگان
چکیده
منابع مشابه
Stimulation by octanoate of insulin release from isolated rat pancreas.
Using pieces of rat pancreas incubated bation medium to 3.0 mg./ml. without in Krebs-bicarbonate buffer containing addition of octanoate produced a slight0.6 mg. glucose/ml., it has been found ly smaller though significant (p < .05) that addition of 3.0 mM. octanoate to increase in insulin release (2.96 t 0.96 the incubation medium significantly (p &J./mg.) above control levels. In con< .OOl) i...
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The modulation of insulin release from the isolated pancreas using normal rats rendered hyperglycemic by in vivo glucose infusion was studied. In 24 h and 48 h hyperglycemic rats , the increase i n the amount of insulin released was reduced in response to glucose challenge , but was unchanged in relation to arginine challenge. In 48 h hyperglycemic rats insulin secretion after glucagon challeng...
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In this study we examined the effect of age and various age-related environmental factors on maximal glucose-stimulated insulin release by the intact perfused pancreas. Male Sprague-Dawley rats were maintained from 40 d to 12 mo of age on standard chow, or on a sucrose-rich or calorie-restricted diet. At 12 mo, studies were carried out on the isolated pancreas of each animal to determine maxima...
متن کاملKinetics of insulin release from the perfused rat pancreas caused by glucose, glucosamine, and galactose.
Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all likelihood common sites of action, it is postulated that a glucoreceptor of broad specificity is inv...
متن کاملEffect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas.
This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 +/- 4 pg/ml. Basal insulin release was less than 20 microU/ml. High glucose (300 mg/dl) conditio...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1984
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.81.7.2199